Various groups and referrals provide help to TSD families. For instance, there is the National Tay-Sachs and Allied Disease Association that provide support to the affected families and individuals in order for them to lead a stress-free life. In addition, there is the National Foundation for Jewish Genetic Diseases, Tay-Sachs Prevention Program, and Late-Onset Tay-Sachs Foundations, Center for the Study and Treatment of Jewish Genetic Diseases and Genetic Alliance Inc. Further services of Genetic counselors have been common and which many families continue to use.

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