Nano-composts and nano-biomaterials have been advanced with the use of various strategies and materials to model architecture and composition of normal bones. Bone tissues may be grouped as nano-composite comprising protein and firm inorganic constituents. Model bone scaffold regeneration has yet to be modelled wholly from bioactive ceramics or bioactive polymers. Ceramics are fundamentally inelastic, delicate and polymeric and do not have the strength to maintain the mechanical forces related with regular bone performance. Composites are potential bone graph material because they integrate the characteristics of different materials. For instance, a polymer–ceramic composite integrates the mechanical features of ceramics with the flexibility and ease of polymer scaffold production.

The composites may be modelled using polymer creation methods to create nano-scale systems in the composite, such as nano-molecules, or nano-fibres. Both in vivo and in vitro research studies have indicated their prospects for bone regeneration.

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