Diverse methods have been applied to combine nano-TCP and nano-HA including solâ€“gel fusion, mechanochemical fusion, wet chemistry, co-precipitation, and micro-emulsion fusion (Venugopal et al. 2008). One popular approach is the solâ€“gel method as it may enhance purity and decrease synthesis temperature when likened to other approaches. Introduction of nano-crystals to composites as bone graft replacements enhances bone cell function (Kim et al. 2006) In vivo research studies illustrate bone development in various nanocomposites and nanomaterials. Injectable artificial adhesive comprising unadulterated nano-sized HA crystals were grafted in the dorsal skinfold cavities in a Syrian golden hamster replica (Laschke et al. 2006).
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